Named for the Ogalala Band of Dakota Sioux that once roamed the western prairies, Ogallala became known as the end of the trail. Cattlemen from Texas drove their herds over the open range on the Chisholm Trail, across the South Platte River, to the Union Pacific railroad at Ogallala. Corralling their herds on Bosler Hill just west of the town, the drovers would go into town to wash down the trail dust at the local saloons and gambling halls.
The Oregon Trail also crossed the South Platte River at Ogallala, at the foot of Bosler Hill. This is the route that Father Pierre-Jean DeSmet S.J., a Jesuit priest from Florissant, Missouri, traveled when he stopped at the south river crossing to instruct and baptize 263 Ogalala Indians in 1859. In an era of gambling, free flowing liquor and bar room brawls, Father DeSmet began to turn the hearts and minds of men to God. It is presumed that since Father DeSmet stayed at Ogallala long enough to instruct and baptize the Indians that he also offered Masses. Father DeSmet was the first to offer Mass in the Diocese of Grand Island.